Category Archives: Clinical pathology

Includes news relating to lab diagnosis of medical conditions.
Discipline groups are Microbiology, Immunology, Anatomical Pathology including cytopathology (cancers etc), Chemical pathology, Haematology and Laboratory management.
EXCLUDES imaging technologies.

Prostate cancer breakthrough could lead to new diagnostic tests and treatments

EurekAlert 28 July 2016

Prostate cancer patients have been offered hope after scientists at Newcastle University, UK, have identified a new group of molecules that could be targeted to slow tumour growth.

Experts used an advanced screening technique which found hundreds of genes were affected by the male hormone testosterone. It is believed this could lead to new diagnostic tests and treatments.

Among the 700 genes identified was an important set that add sugar groups – known as glycans – to the surface of prostate cancer cells. This group has never been investigated before.

Results of the research, published in EBioMedicine, suggest that testosterone changes glycans to make cancer cells more likely to survive, grow and spread to other parts of the body.

Scientists say there is the potential to target these glycans which could stop the growth and spread of tumours and save lives.

Read more http://www.eurekalert.org/pub_releases/2016-07/nu-pcb072816.php

View the source article http://www.sciencedirect.com/science/article/pii/S2352396416301530 (Open Access)

Liquid biopsies offer hope for earlier treatment, better tracking of ovarian cancer

(Mayo Clinic 20 July 2016) Researchers at the Mayo Clinic Center for Individualized Medicine have found a promising new way to monitor and treat recurrence of ovarian cancer — a hard-to-detect disease that claims many lives. New research from George Vasmatzis, Ph.D., of the Department of Laboratory Medicine and Pathology at Mayo Clinic, finds liquid biopsies from blood tests and DNA sequencing can detect a return of ovarian cancer long before a tumor reappears.

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Researchers produce first widely protective vaccine against chlamydia

(McMaster University 19 July 2016) The first steps towards developing a vaccine against an insidious sexual transmitted infection have been accomplished by researchers at McMaster University.

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Smell test may predict early stages of Alzheimer’s disease

(Columbia University Medical Center) An odor identification test may prove useful in predicting cognitive decline and detecting early-stage Alzheimer’s disease, according to research presented at the Alzheimer’s Association International Conference.

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Scientists find antibiotic in nose

Gold Coast Bulletin AAP 28 July 2016

Scientists in Germany have discovered a bacteria hiding out in peoples’ noses that produces an antibiotic compound that can kill several dangerous pathogens, including the superbug MRSA.

The early-stage finding, reported in the journal Nature on Wednesday, could one day lead to a whole new class of antibiotic medicines being developed to fight drug-resistant bacterial infections, the researchers said.

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First ever whole genome testing in Australia opens at the Garvan Institute

Brisbane Times Kate Aubusson 27 July 2016

Testing labs usually analyse just one gene, or a panel or genes, at a time.  But Australia’s first whole genome testing service will be able to analyse all 20,000 genes from one blood test.  The Garvan Institute’s Genome.One – one of the first clinical whole genome sequencing services in the world – is capable of sequencing an individual’s entire genetic information.  The service could triple diagnosis rates among people with rare unknown genetic diseases.

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No proof found linking Sydney dental clinics to infectious disease cases

ABC News Justine Kearney, ANdrew Griffits 28 July 2016

New South Wales health authorities have found no conclusive evidence linking four private Sydney dental clinics to patients with infectious diseases, including HIV and hepatitis.  The report found the available evidence to be inconclusive as to whether those patients were infected during invasive procedures at the dental clinics or from other sources.

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