EurekAlert! | Gina DiGravio 27 July 2016
A newly identified requirement of a modified human protein in ebolavirus (EBOV) replication, may unlock the door for new approaches to treating Ebola.
EBOV is one of the most lethal human pathogens known and causes severe hemorrhagic fever in humans. When EBOV makes copies of itself inside cells, it does so by taking over and hijacking parts of that host cell’s basic machinery to make its own proteins. The most recent outbreak in 2014 has illustrated the lack of understanding of viral pathogenesis and highlighted the need for increased study of how the Ebola virus replicates.
Read more: http://www.eurekalert.org/pub_releases/2016-07/bumc-rip072616.php
View open-source study at mBio: http://mbio.asm.org/content/7/4/e00882-16
Posted in Virology
Tagged Ebola, USA
EurekaAlert Jim Fessenden 22 June 2016
WORCESTER, MA – Scientists at the University of Massachusetts Medical School (UMMS) have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication. This work, led by Abraham Brass, MD, PhD, assistant professor in microbiology & physiological systems, reveals new leads that may be useful for halting Zika, dengue and other emerging viral infections. The study appears online in the journal Cell Reports.
“These genetic screens give us our first look at what these viruses need to survive,” said Dr. Brass. “Our lab and others in our field have worked hard to develop the systems and infrastructure needed to investigate the genetics underlying how viral pathogens use our own cell’s machinery to replicate. This has allowed the scientific community to respond quickly when the Zika virus threat emerged. In our lab, we adapted the technology and tools we’d established over the last four years working with other viruses to begin investigating the biology of Zika virus.”
Read more: http://www.eurekalert.org/pub_releases/2016-06/uomm-usu062116.php
EurekaAlert Mary Ann Liebert 22 June 2016
New Rochelle, NY, June 21, 2016– A new study demonstrating the conversion of oral cannabidiol (CBD) to the psychoactive component tetrahydrocannabinol (THC) in the presence of gastric fluids could explain why children given CBD to treat epilepsy had an unexpectedly high rate of adverse effects such as sleepiness and fatigue. The study, “Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiologic Fluid”, is published in Cannabis and Cannabinoid Research, a new peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Open Access Journal website.
Read more: http://www.eurekalert.org/pub_releases/2016-06/mali-doc062116.php
Brisbane Times Lena H. Sun and Brady Dennis May 27 2016
For the first time, researchers have found a person in the United States carrying a bacteria resistant to antibiotics of last resort, an alarming development that the top US public health official says could mean “the end of the road” for antibiotics.
The antibiotic-resistant strain was found last month in the urine of a 49-year-old woman in the US state of Pennsylvania. Department of Defence researchers determined that carried a strain of E. coli resistant to the antibiotic colistin, according to a study published on Thursday. The authors wrote that the discovery “heralds the emergence of a truly pan-drug resistant bacteria.”
Read more: http://www.brisbanetimes.com.au/world/the-superbug-that-could-render-antibiotics-useless-just-hit-the-us-20160526-gp4yl3.html
Link to Abstract & Full-text article: http://aac.asm.org/content/early/2016/05/25/AAC.01103-16.abstract
ABC News article: Drug-resistant superbug bound to reach Australia in time, expert says
Read here: http://www.abc.net.au/news/2016-05-27/only-a-matter-of-time-before-superbug-reaches-australia/7451726
TripleJ 9 Mar 2016
The documentary series Making a Murderer tells the story of Steven Avery, who spent 18 years in prison for the rape and attempted murder of a woman in Wisconsin before he was exonerated on DNA evidence.
He was suing law enforcement for $36 million in compensation for the wrongful conviction when police arrested him again – this time for the murder of another local woman – Theresa Halbach.
Australian viewers might wonder: could that happen here?
Hack sat down with Laura Ricciardi and Moira Demos, the pair who wrote and directed the highly acclaimed true crime series, to talk about how the Avery’s story is an insight into the ways a criminal justice system can fail – how conflict of interest and bias can lead to the wrong person going to jail for decades.
Read more: http://www.abc.net.au/triplej/programs/hack/making-a-murderer-could-it-happen-in-australia/7234572
American Public Health Association, American Water Works Association Mar 16, 2016
This complimentary webinar is brought to you by AWWA and APHA. March 16, 2016 | 11:00 a.m. – 12:30 p.m. MT
The recent reports of elevated blood lead levels in children in Flint, Michigan have placed a national spotlight on the role of drinking water in lead exposure. As the events continue to evolve, important questions are being raised about changes in drinking water chemistry, what can be done to control lead exposure through drinking water, and how local water utilities and the public health community can work together. Join APHA and the American Water Works Association for an interactive discussion about the current state of science related to the health risks posed by lead and the value of engaging the water systems sector.
Register here: https://cc.readytalk.com/cc/s/registrations/new?cid=mvxysquc8jku
ABC News 10 February 2015
The number of measles cases in the United States is rising, with some states considering enforced vaccinations.
The US Centres for Disease and Control (CDC), which began tracking the outbreak on January 1, said the measles outbreak had now spread to 17 states and Washington DC.
It said the vast majority of the 121 confirmed cases were part of the large outbreak that began at California’s Disneyland amusement park in December.
The latest figures put the US on track to surpass the 644 cases it experienced last year.